Nuovo soggettario e WebDewey italiana: strategie di mapping e integrazione

The National Central Library of Florence takes care of and develops semantic indexing tools which are usable in libraries, archives, museums, and other cultural institutions. In the last few years, the interoperability between Nuovo Soggettario and other knowledge organization systems, accessible for free on the Web, has increased significantly in order to give users the opportunity to search and identify relevant information from among vast collections and other resources. In this context, one of the most interesting experiences has been the mapping between Nuovo Soggettario Thesaurus’s concepts/terms and DDC’s concepts/notations (in WebDewey Italian version) established and maintained by the BNCF. The criteria adopted for the creation of concordances between equivalent concepts are being clarified continually and are in compliance with the latest international standards and suggestions of the EDUG group (European DDC Users Group). Thanks to the collaboration with AIB, the interaction between the two tools is visible not only in the record of Nuovo Soggettario terms but also in the WebDewey (IT) notations in which the Nuovo Soggettario verbal equivalents are next to those of the LCSH

Thirty years of Dewey in Italy: the role of the National central library of Florence and the latest developments in terms of interoperability with other indexing tools

The aim of this article is to provide a historical overview of the Dewey Decimal Classification with particular regard to the BNCF role, starting from the first Italian translation in 1897 and continuing with the design and development of the Dewey notation's archive in the National library service's (SBN) OPAC, and with the adoption of the DDC for the Italian national bibliography (BNI). Since 2014 the BNCF has been involved in the Italian translation of the WebDewey, and is now working on its interoperability with the Nuovo soggettario Thesaurus, with particular regard to the semantic and technical criteria for the creation of concordances between equivalents concepts. These criteria are in compliance with ISO 25964 and with the recommendations of the European DDC users group (EDUG).La diffusione in Italia della Classificazione decimale Dewey ha beneficiato sin dalle origini del ruolo svolto dalla Biblioteca nazionale centrale di Firenze, che nel 1897 ne ha curato la prima traduzione italiana e che dal 1958 ha impiegato notazioni ridotte per i fascicoli della Bibliografia nazionale italiana. Con la nascita di SBN e del Polo BNCF le attività legate all'impiego della DDC si sono ulteriormente sviluppate. Dal 2014 infine, con l'inaugurazione dell'interfaccia della WebDewey italiana, il ruolo della Biblioteca nazionale di Firenze continua seppur con caratteristiche diverse. La BNCF infatti è il curatore scientifico della WebDewey italiana, e parallelamente si occupa delle problematiche legate alla sua potenziale interoperabilità con il Thesaurus del Nuovo soggettario. L'esperienza in atto e i criteri di mappatura adottati per la creazione di concordanze fra concetti equivalenti sono conformi alle indicazioni dettate dallo standard ISO 25964, e ai suggerimenti del gruppo EDUG (European DDC users group)

The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression

Ion channels regulate cell proliferation, differentiation, and migration in normal and neoplastic cells through cell-cell and cell-extracellular matrix (ECM) transmembrane receptors called integrins. K+ flux through the human ether-\ue0-gogo- related gene 1 (hERG1) channel shapes action potential firing in excitable cells such as cardiomyocytes. Its abundance is often aberrantly high in tumors, where it modulates integrin-mediated signaling. We found that hERG1 interacted with the \u3b21 integrin subunit at the plasma membrane of human cancer cells. This interaction was not detected in cardiomyocytes because of the presence of the hERG1 auxiliary subunit KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1), which blocked the \u3b21 integrin-hERG1 interaction. Although open hERG1 channels did not interact as strongly with \u3b21 integrins as did closed channels, current flow through hERG1 channelswas necessary to activate the integrin-dependent phosphorylation of Tyr397 in focal adhesion kinase (FAK) in both normal and cancer cells. In immunodeficient mice, proliferation was inhibited in breast cancer cells expressing forms of hERG1 with impaired K+ flow, whereas metastasis of breast cancer cells was reduced when the hERG1/\u3b21 integrin interaction was disrupted. We conclude that the interaction of \u3b21 integrins with hERG1 channels in cancer cells stimulated distinct signaling pathways that depended on the conformational state of hERG1 and affected different aspects of tumor progression

Structural studies on iminophosphine ligands and their palladium complexes

The crystal and molecular structures of the iminophosphine o-(Ph2P)C6H4CH=NC6H4OMe-4 (1) and its palladium complexes [Pd(3-C3H5){o-(Ph2P)C6H4CH=NC6H4OMe-p}]BF4 (2) and [Pd(2-fn){o-(Ph2P)C6H4CH=NC6H4OMe-4}] [fn=fumaronitrile, (3)] have been determined by X-ray analysis. In the free ligand (1), the planar imino group of E configuration is oriented, relative to the PPh2 unit, so that the CH=N hydrogen atom points towards phosphorus, with the nitrogen atom on the opposite side. In (2) and (3) the iminophosphine behaves as a P,N-chelate ligand, this coordination mode being achieved by the imino group rotation of 169.3\ub0 and 145.3\ub0, respectively, around its bond with the ortho disubstituted phenyl ring. Complex (2) shows a structural disorder with two different orientations of the allyl ligand. The trigonal planar coordination around the central metal in complex (3) involves the P- and N-donor atoms of (1) and the 2-bound olefin, with a marked lengthening of the olefinic carbon-carbon bond. In both the complexes, the chelate six-membered ring of the iminophosphine with palladium is not coplanar with the N-Pd-P coordination plane, the imino carbon atom and the ortho disubstituted phenyl group lying on the same side out of the N-Pd-P plane, whereas the N-substituent and one of the PPh2 groups are on the opposite side. The 1H-n.m.r. spectra at low temperatures of (2) and (3), and of [Pd(2-tmetc){o-(Ph2P)C6H4CH=NCMe3}] [tmetc=tetramethyl ethylenetetracarboxylate, (4)] are interpreted on the basis of a non-rigid conformation of the chelate iminophosphine, which undergoes a fast dynamic process whereby the N- and P-substituents move above and below the coordination plane

Nuovo soggettario e DDC

The team of Italian National Bibliography (BNI) wanted the Dewey Classification be an important component of the Nuovo soggettario as the classification is able to represent a bridge towards indexing systems in other languages. Linking DDC numbers to the completely structured terms of the italian Nuovo Soggettario makes the maximum integration and interoperability between the two distinct indexing systems possible. The work was carried out using specific criteria and the problems that occurred derive from the different structure of the two tools and some language differences concerning terms and their meaning. One of the most pressing needs of the BNI team is to refine operative criteria in order to continue this project

Incorporation of the zosteric sodium salt in silica nanocapsules: synthesis and characterization of new fillers for antifouling coatings

In the last decade many commercial biocides were gradually banned for toxicity. This work reports, for the first time, the synthesis and characterization of silica nanocontainers loaded with a natural product antifoulant (NPA), the zosteric sodium salt which is a non-commercial and environmentally friendly product with natural origin. The synthesis approach is a single step dynamic self-assembly with tetraethoxysilane (TEOS) as silica precursor. Unlike conventional mesoporous silica nanoparticles, the structure of these silica nanocontainers provides loading capacity and allows prolonged release of biocide species. The obtained nanocapsules have been characterized morphologically by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The encapsulation was checked by FTIR ATR spectroscopy and thermogravimetric analyses. The results of the release studies show the great potential of the here presented newly developed nanofillers in all applications where a controlled release of non-toxic and environmentally friendly biocides is required